McCaffrey limped off the field and straight into the injury tent after the play, and was seen heading to the locker room accompanied by trainers shortly after. The team provided an update indicating ...

San Francisco running back Christian McCaffrey was officially ruled out of the 49ers’ Sunday Night Football contest at the ...

The biggest storyline entering the Buffalo Bills' Week 13 clash with the San Francisco 49ers was the snow, but it was no issue for Mack Hollins.

Josh Allen grabbed at his left hand and jumped in pain after he took on 49ers linebacker De'Vondre Campbell Sr.

Buffalo has looked much more comfortable playing in the snowy conditions, scoring three TDs in the first half on Sunday.

San Francisco 49ers fans held their collective breath Sunday when Christian McCaffrey went down with a non-contact injury in ...

The Bills return from their bye and will look to keep pace with the Kansas City Chiefs at the top of the AFC. Josh Allen has ...

Buffalo has run consistently over the previously perceived vaunted 49ers defense to jump up to a halftime lead.

Christian McCaffrey was off to a great start in Sunday night's matchup with the Bills but had to exit the contest early in ...

Heavy snowfall and numbing temperatures kept parts of the U.S. in a deep freeze Sunday as the Thanksgiving holiday ...

San Francisco 49ers cornerback Renardo Green breaks up Buffalo Bills quarterback Josh Allen's improvised loft to Bills wide ...

San Francisco 49ers kicker Jake Moody's 33-yard field goal helps 49ers strike first on 'Sunday Night Football' against the ...