Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

All the information now known on the Bills' 2025 schedule can be found below: Week 1: TBD. Week 2: TBD. Week 3: TBD. Week 7: BYE. Our team of savvy editors independently handpicks all recommendations. If you make a purchase through our links, we may earn a commission. Prices were accurate at the time of publication but may change.

Ahead of the Buffalo Bills learning their 2025 NFL schedule this week, here are some predictions and analysis for their season.