Peppers hadn’t played since Sept. 29, when the Patriots lost 30-13 at San Francisco. He walked with a slight limp in the post-game locker room, and was listed as questionable on the team’s final injury report with a hurt knee. His status moving forward is unknown.

Peppers was dropped from the Commissioner’s Exempt List and reinstated by the NFL earlier in the week. He hasn’t played since the team’s Week 4 loss to the San Francisco 49ers. Meanwhile, Wise has missed the last two games due to a foot injury.

The Indianapolis Colts will have wide receiver Alec Pierce back on the field as they visit the New England Patriots, who will see the return of safety Jabrill Peppers, on