Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

ORCHARD PARK, NEW YORK - JANUARY 19: Lamar Jackson #8 of the Baltimore Ravens and Josh Allen #17 of the Buffalo Bills embrace after the AFC Divisional Playoff game at Highmark Stadium on January 19, 2025 in Orchard Park, New York. (Photo by Al Bello/Getty Images) Getty Images

For starters, they won't be suffering from much jetlag in 2025—Cincinnati travels a combined 8,753 miles in 2025, the least in the league. A chunk of that travel comes early in the season, with four of their first six games away from home.

The Patriots' 2025 schedule has no shortage of intriguing games, including matchups against the Bills and the Bengals.

In a surprise, one of the games the Buffalo Bills are playing in 2025 is amongst the most coveted contests across the entire NFL next season. The league released the entire schedule for the upcoming year this week, including the Bills' slate.

Every NFL schedule presents unique challenges for teams but we picked the toughest for the Bucs on the 2025 schedule.

The seven prime-time games the Chiefs are in ties an NFL record with the 2023 Buffalo Bills, who ended up being flexed into a prime-time slot in Week 18 to previously set the record. The NFL scheduled the seven prime-time games for the Chiefs due to their loaded schedule of opponents.

With the Texans' 2025 schedule out, The Houston Chronicle's Jonathan M. Alexander makes his week-by-week predictions for all 17 games.